Not All Depression Is the Same: Understanding Treatment-Resistant Depression

Depression is one of the most common mental health struggles people face, and yet, it can still feel incredibly isolating when you’re the one going through it. If you’ve been living with low energy, a loss of interest in things you used to enjoy, or an
overwhelming sense of sadness, you’re not alone. And if you’ve already tried therapy, medication, or even both but haven’t felt much relief, you might be wondering what’s wrong or why nothing seems to work.

We want you to know it’s not your fault. Some types of depression just don’t respond to traditional treatment. This is called treatment-resistant depression, or TRD.  Some cases of depression are difficult to treat. It’s not a reflection of how hard you’ve tried or how strong you are. It’s simply a more stubborn form of depression that needs a targeted approach.

What’s The Difference Between Treatment-Resistant Depression and Depression?

Most people are familiar with the idea of depression. Feeling down, low energy, loss of motivation, and difficulty sleeping or eating are all common symptoms. And for many, therapy or antidepressants can bring real relief over time. But what if you’ve tried all of that… and still feel stuck?

Treatment-resistant depression (TRD) isn’t a different diagnosis altogether. It’s a form of major depressive disorder that hasn’t responded to at least two standard antidepressant medications taken at the correct dose for a long enough time. In other
words, you’ve done your part. You’ve tried. And yet, the symptoms continue.

The most significant difference between depression and TRD lies in how the brain responds to treatment. With typical depression, the brain may respond well to medications that affect serotonin or other mood-related chemicals. But with TRD, those same medications often don’t make a dent, or they may help a little, only for symptoms to come right back.

Many people living with TRD have spent years trying different antidepressants, changing doses, switching therapists, or being told to “just hang in there.” After a while, it can start to feel hopeless. But TRD is more common than you might think. More importantly, there are innovative, evidence-based treatments that are changing lives
every day.

If you’ve been silently asking yourself, “Why do I still feel like this?” or “Will anything ever help?”, we hear you, and we’ve helped many people who feel the same way.

Spravato®: A Prescription Nasal Spray For Treatment-Resistant Depression

Spravato® is a nasal spray made for people who have what’s called treatment-resistant depression. That means your depression hasn’t gotten better, even after trying at least two different antidepressants. Spravato® works differently from regular medications and can help people feel relief more quickly. It’s used along with an oral antidepressant and given in a safe, comfortable clinic setting, where you’re cared for during and after each treatment.

This prescription nasal spray for depression may help improve mood, energy, and overall well-being when other treatments haven’t worked. For many people, it brings a sense of hope after months or years of struggling with no answers. It’s not
about trying harder—it’s about finding the right kind of care. If you’re in Long Beach or Irvine and wondering if anything will ever help, Spravato® could be the next step toward feeling better.

TMS Therapy: A Non-Invasive, Drug-Free Depression Treatment

TMS Therapy, or Transcranial Magnetic Stimulation, is another treatment we offer that can help people who have depression that hasn’t gotten better with medication. It uses gentle magnetic pulses to target the parts of the brain involved in mood. The
treatment is non-invasive, which means there are no needles or surgery, and you stay awake the whole time. Many people find TMS helpful because it doesn’t cause the same side effects as some antidepressants. We administer the sessions at our office; most take less than an hour.

If you’ve been living with treatment-resistant depression, TMS can offer a new kind of hope. If you’ve been living with treatment-resistant depression, TMS can offer you a new kind of hope. TMS Therapy helps people who feel like they’ve tried
everything but are still struggling. TMS works in a different way than medicine, helping to “wake up” the areas of the brain that may not be as active during depression. Over time, it can improve mood, energy, and focus. If you’re tired of feeling stuck, TMS could be a safe and effective option to help you feel more like yourself again.

Beat Depression At Pacific Mind Health

These innovative depression treatments work differently than traditional medications and they’ve made a real difference for people who felt like nothing else helped.

We understand how exhausting it is to keep searching for answers. That’s why we’re here to help you finally find relief, with no waitlist and immediate availability in Long Beach and Irvine.

You deserve to feel better. And when you’re ready, we’ll be here with support that meets you where you are.

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